Puke my pants Share definition Flag A kind of gastro-intestinal disorder usually caused by Ingesting the wrong thing at the wrong time. I chased that sushi with a warm Pabst, and now I gotta Puke my pants. Puke my pants by Bigger sam August 27, 2008 0 0 Get merch Get the Puke my pants mug. Buy Now — $32.95 See more merch