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A shortened version of "pick your shit up and get the fuck out", an insult similar to "Piss off" but with emphasis to the person's personal belongings and or problems.
Chunky told George to Pick Off! when he was being rude and impolite.
by chunky pawps July 16, 2015
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2
a prostitute; slut; a person who sleeps with so many guys
Sarah slept with 5 guys. She's such a pick off.
by LoL@27 December 03, 2017
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