The jealous over-reaction of a domestic partner when a friend and/or acquaintance is engaging in conversation with his/her significant other.
Luke doesn't want to go to the bathroom because he thinks his girl Krystin is gonna get gang banged by his friends while he's pissing, classic example of Osbourne Syndrome.
by JRickDaBOSS January 19, 2012
Get the Osbourne Syndromemug.