'Nup' is the opposite of 'Yup'

Nup means you don't want to do something, or you disagree with something.
Dave- "Wanna go to the movies bro?"

Mikey- "Nup bro. I just wanna relax."
by Nupqueen00 July 29, 2014
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What some woman say when they are mad at you
Brandon: Are you mad at me?
Viv: Nup
by Venom15495 October 4, 2018
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1)A word said to someone who has either said or done something stupid, gay, ridiculous or asks a question already answered multiple times.

2)Expression of disbelief, usually over something too good to be true.

Can be described as another way of saying 'get out'.
1)Person1: These four lokos taste soooo good its like an orgasm in the mouth.
Person2: Ok NUPPP

2) Person1: I drank 6 four lokos, 24 beers and was only buzzed last night.
Person2: Nup
by Nupp August 4, 2011
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A third nipple, someone likely to have a third nipple. It can be any part of speech.
Nup! I spilled coffee on myself!
by N.Sinclair May 31, 2011
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this is a bum sex word.. cant get any better. if theres an uncomfortable silence, just yell NUP NUP NUP and everything turns out okay... usually yelled out in the middle of maths if one is bored or has one of those impulses. never be afraid to yell NUP NUP NUP
*a girl is sitting totally bored and dying in math class. she stands up* hmmm omy everyone---NUP NUP NUP!!!!!!
by Cimarron March 27, 2003
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the half asleep zombie trance of a liberian boy high on heroin.
this boy is nupping. he's nupping. you smoke heroin and you want to sleep, but you don't sleep, so he's nupping.
only cocaine will calm him down.
by ius1 February 24, 2010
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(abbreviation) nuptials; a wedding or a marriage.
Did you see that couple that danced down the aisle at their nups? Best entrance ever.
by LegalDonut August 12, 2009
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