1. To fail at the most simple of tasks.

2. To mess up an otherwise cakewalk scenario.
1. Woah, dude. You just Mayreni'd that big time.

2. How did you miss that headshot? That guy is AFK!!! Way to MAYRENI!!
by Justice_Avenue February 08, 2010
Get the mug
Get a Mayreni mug for your Uncle Trump.