A mixture of the words "loaf" and "hopeless". When you are loafing about and start thinking of everything you should be doing. This makes you feel sad and leads to you thinking of everything else you have done wrong in life, causing you to loose hope in the process.
Friend: Hey dude, you want to come over and hang?
Subject: Sorry dude, I'm feeling utterly loafless at the moment.
Friend: ... ok... You wanna talk about it?
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.