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It's not you, it's me. 

When ur partner wants to break up with you. They tell you, "It's not you, it's me." It basically means, I wana dump u cos ur mingin and that guy/bird over there is miles fitter, so l8r loser...
Ur holding hands with ur b.f/g.f and are smitten with each other, when suddenly, this really fit guy/girl walks by, you can see your partner druelling @ the site of them. They tell you that its not working and that, "Its not you, it's me."
It's not you, it's me. by LoZzA April 30, 2004

it's not you, it's me 

I no longer find you attractive, but I can't say that because then I'll feel guilty. Oh, by the way, good riddance.
Girl: Listen, Harry, we need to talk...

Harry: huhuhuh whatfor sexy hot girl?

Girl: Look... it's not you, it's me. I don't think this is working out.

it's not you, it's me 

female slang for: It is you.
after the bitch chased me down the street with a knife, i told her "it's not you, it's me"

it's not you, it's me 

A great excuse for breaking up with someone while trying not to hurt their feelings.
Famously used by George in Seinfeld, he gets upset when he found out someone used his line and claims he invented it.
"Dan I really like you but I think it's over between us."
"What? Why? What did I do?"
"It's not you, it's me."
it's not you, it's me by Sarah July 18, 2004

it's not you, it's me 

Something bitch ass unoriginal pussies say.
Hey babe, look, it's not you, it's me. I need to figure things out. Like why I'm such a fucking pussy."
it's not you, it's me by Azuzu March 13, 2009

it's not you, it's me 

The reason one gives when terminating a relationship with someone who turns out to be repulsive and/or mind-numbingly boring.
It's not you, it's me...I'm just not attracted to you.
it's not you, it's me by Aw yeah August 24, 2004