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Short for "It's A." It was commonly used as slang before the famous 21 Savage interview where he mentioned his knife tattoo.
Int: What does the cross on your forehead signify?
21 Savage: Issa knife.
Issa by issawife November 28, 2016
Related Words

Issa Kiggy 

When you see a cute cat, typically a chonky one :)
Issa Kiggy by Ginmi September 5, 2019

Issaq Dheen

This is a an Asian slang used to denote anything and everything but no. It embodies the Asian CAN-DO attitude and is the equivalent of the American military's "HOOAH".

"Don't be an Issaq Dheen."
"Hooah, this is pretty Issaq Dheen."
"Life is an Issaq Dheen."
"The only certainty is Issaq Dheen."
"Issaq Dheen is a virtue."
"Live life like an Issaq Dheen!"
Issaq Dheen by Sahveeo October 25, 2006

Issac Moment 

When the conversation gets too weird, like really really weird, hey I mean like really fuckin weird

In other words intense
Ashraf: Yo have u seen this documentary of a whole tribe of chicken located in Africa fuckin each others using armpits only !

Nada: Stop it w the Issac stuff

Adham: that's an Issac Moment
Issac Moment by VNGLOU December 13, 2020

issa snack 

issa meaning "it's a " and together issa snack is reffering someting so good you'd like to snack on it.
issa snack by blueberrydelilah February 27, 2017
A self made person, generous and compassionate, handsome and sexy, he is gentle with his female companions, very compassionate lover.
He pulled himself from poor to riches, he is ISSAM.
Issam by Chief Pilot December 5, 2017