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A mythological creature, often useless and bad at everything it does.
Man, you're such a gui ...
by Nubita June 29, 2016
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a gender-neutral way to reclaim and say the word "guys" when addressing multiple people at once.
Me: "Hey guis, what's up"
Everyone (collectively): "Hey, what's up, Donna"
via giphy
by bes_ame April 12, 2018
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Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
by AYB April 04, 2003
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A Graphical User Interface. The addition of GUI's to most modern operating systems has revolutionised the populous' ability access pornographic material, and contributed greatly to the happiness of the single geek/male population.
Oh dude, this pussy looks so hot in HD, thanks to my GUI!
by Axman6 January 25, 2008
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5
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009
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Stands for "Genius Under the Influence". It is a term used for individuals who come up with fantastic ideas when abusing some kind of substance, or for those students who actually do quality schoolwork while completely fucked up.
Student # 1: "I can't believe I got an 'A' on that paper. I was so high when I did it I couldn't even remember what I wrote about."

Student # 2: "WTF. You should totally be charged with a GUI."
by GreenParrot713 October 26, 2009
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