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A mythological creature, often useless and bad at everything it does.
Man, you're such a gui ...
by Nubita June 29, 2016
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Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
by AYB April 04, 2003
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3
A Graphical User Interface. The addition of GUI's to most modern operating systems has revolutionised the populous' ability access pornographic material, and contributed greatly to the happiness of the single geek/male population.
Oh dude, this pussy looks so hot in HD, thanks to my GUI!
by Axman6 January 25, 2008
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4
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009
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6
Stands for "Genius Under the Influence". It is a term used for individuals who come up with fantastic ideas when abusing some kind of substance, or for those students who actually do quality schoolwork while completely fucked up.
Student # 1: "I can't believe I got an 'A' on that paper. I was so high when I did it I couldn't even remember what I wrote about."

Student # 2: "WTF. You should totally be charged with a GUI."
by GreenParrot713 October 26, 2009
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pronounced as Jooey: Sometimes you just cant decide wether you'd rather play some good old fashioned COD or get a nice blow from your girlfriend. Why not settle for both. This is where the GUI come in... Gaming under the influence. Now you can play with both sticks at the same time.

This the ultimate gaming experience. So get your girl, get your XBox and get under the influence.
Tommy was ignoring his girlfriend Laura, being he was in the middle of level 27 on Nazi Zombies. In order to resolve this conflict Laura proposed a GUI, which allowed him to keep his tip wet and destroy some zombies all at the same time.
by Lulu&AmDam October 25, 2010
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