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A combination of the names George and Izzie.
Comes from the television show Grey's Anatomy. Fans of the show use it to refer to the relationship between George O'Malley and Isobel "Izzie" Stevens.
Oh my Gawd, Gizzie is so retarded. He should have just stayed with Callie.
by eulalie27 May 13, 2008
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(N.) A stupid, assclown who likes Anti-rap like Ja Rule and Too Short. Suck a d*** you stupid skank!
This dumb Gizzie Mcguire bitch likes DJ Too Dope and Ja Rule. Let's throw some 99 cent "Irv Gotti Presents.." albums at her bitch ass!
by G-Union May 12, 2003
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To use instead of the word go but in a work related context.
Hey porkchop! What's on the gizzie?
by Ewhizzle Enwhizzle January 18, 2004
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