FannyPickle Share definition Flag An STD/STI only women can get. It makes the vagina prickly and tough to handle.Also a rage word. Girl 1: I crud I have FannyPickle! Girl 2: Uh oh! Go and see an doctor!! Girl 1: It hurts! FannyPickle by ADAM THE MONG December 2, 2011 Get the FannyPickle mug.