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1. A chemical or substance that depresses the nervous system. e.g. alcohol.Often addictive.

2. A person who ruins everyone elses fun.

3. A relationship.

4. A member of the opposite sex.
John-"Hey whats wrong with you Timmy?"

Timmy-"I am full of this depressant," Points to a bottle of cheap vodka, "Because I'm still living with this depressant." points to expensive, unloving woman.
by Dry Rubber Chicken July 22, 2010
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someone who, when seen or spoken to, illicits a downer affect on your mood and emotions.
I was in such a great mood until I talked to Brandi. She is such a depressant.
by Scroty-G October 06, 2009
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