Bumhole Syndrome Share definition Flag The side effects of a drug or action used to stretch the anus, meaning the anus is open and very loose. Roy- "How was your weekend Paul?" Paul- "Terrible, I fell on a pole and I got Bumhole Syndrome" Bumhole Syndrome by o0 I3LACKOUT Oo September 28, 2008 0 0 Get merch Get the Bumhole Syndrome mug. Buy Now — $32.95 See more merch