Ambi-sassing Share definition Flag To get mouthy or to start "fresh-talking" to someone whilst under the influence of Ambien "Go to bed, goddammit, you're Ambi-sassing me and I don't appreciate it!" Ambi-sassing by Miss Man Hands March 16, 2014 0 0 Get merch Get the Ambi-sassing mug. Buy Now — $32.95 See more merch