Lose the plot 

To lose the ability to cope with or understand what's going on around you.

Feminist Frequency is complaining about lack of diversity in female character designs in OverWatcth, a game that went out of its way to have the most diversity in female character designs. Way to lose the plot, Feminist Frequency!

Lose the plot by JohnSmith1495 September 3, 2016

lose the willy

A really fat person who believes they look slimmer in expensive designer clothing brands.

Hey Tubs, you better 'lose the willy' if you wanna wear Prada.

lose the willy by Disco Dave December 3, 2007

lose yourself

something that one does in a forest

so you have debts? lose yourself in a forest and get family members to collect your life insurance

lose yourself by General Array of Yetis November 18, 2003

lose a bet 

When one of your friends arrives with an ugly date.

Damn Katie, did you lose a bet?

lose a bet by T. M. December 26, 2005

lose yourself

getting caught up in the moment

"I lose myself when I'm alone with my boi"

lose yourself by JustaGurl September 4, 2003

lose my squash 

To completely unravel in a large explosion of anger, frustration, and exasperation (aka the triumvirate of despair.) Derived from of "out of my gourd."

Dude, if Trump says "locker room talk" one more time I'm going to lose my squash.

If one more person asks me something they could Google and find out I'm going to lose my squash.

lose my squash by RedHeadMeag October 13, 2016

lose a 50/50 

when you fart and there is a fifty fifty chance you may shit yourself. if you crap your pants you lose a fifty fifty.

i was laying in bed the other night and thought i only had to fart. i was worried i could lose a 50/50. i let it go and was a big loser.

lose a 50/50 by poopmypants December 18, 2008