An area in Eastern Long Island densely populated with old world Italians.
``Hey, Vito, you want to go with me to visit grandpa in Old Guinea?''
by tirtle January 10, 2017
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Sgt. O'Mally is a real Guinea Pig. I saw him down at the docks taking a bribe from one of the Don's goons, while they were unloading some Coke.
by Captain Kangaroo May 4, 2006
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PERSON 1: HEY, I GOT A GUINEA PIG!
PERSON 2: WOW, GUINE PIGS ARE AN AWESOME PET! THEY ARE ADORABLE
PERSON 1: YEAH!
by DA GUINEA PIG WHISPERER March 3, 2020
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The cutest little animal in the world. They have a chubby body and no tail and they can come in a variety of different colours. Eats most vegetables and some fruits. Guinea pigs love fresh hay and grass. Also called cavy
by S December 28, 2005
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1. Someone or something that is used to test medicine or other products and procedures.

2. A small South American rodent that looks like a miniature capibara and is kept around the world as a pet. Also used as a food in its native range.
1. Fred is a guinea pig for a pharmeceudical company and gets paid for the testing.

2. One of the class animals in my biology class is a guinea pig.
by Steve December 14, 2004
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More likely to appear as the racial epithet "guinea nigger", common to portions of the northeastern South, and referring to any black of mixed race, especially to those with strikingly red hair, well into the mid-20th century. Common in east-central WVa. The melding of black and Nordic Caucasian bloodlines is likely to yield the trait, wherein the hair colors of pure black and pure blonde became red - the third pure hair color. It's quite specific to the blazing red hair - different, e.g., from "high yellow." (I heard it in my youth during the 40s and 50s, moved from the area, and have not since encountered it. Sadly, in that area at least, neither blacks nor whites would claim kinship with them and as often as not shunned them, so that they commonly chose to live in isolated communities among themselves.)

This is an uncomfortable exercise, as the usage is historic but most certainly deprecatory. Looking for common usages, etc., is simply in bad form. It existed, may yet be utilized, and is an insult.
There was a Guinea negro (actually guinea nigger) community near Philippi.
by poppa2 October 14, 2013
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A big, fat, smelly cigar favored by older Italian-American men.
Look at that guinea stinker Tony has in his mouth.
by italian-stallion April 17, 2007
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