as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")
Uncle Jimmies Porn Emporium is a place of peace, strippers and ANAL. On the inside of this palace of PORN is just a great big wonderful rainbow of bondage, lesbians, etc. So come on down to Uncle Jimmies Porn Emporium, we do not condone eggs
To "russle" someone's "jimmies". Another definition would be to give someone a boner and/or erection. Further symptoms may be orgasms and feeling horny. Only effects males.