From the word whore; how the word sounds when used by people who have trouble with the letter R at the end of a word (examples: sure, "sho"; more, "mo"; for, "fo").
A women who fucks other gurls or guys while going out wif sumone
Someone who cheats on their partner
Jess is the biggest fucking ho i've ever met. She was going out with Mike for about 10 minutes before she got fingered by Jay and Rick (at the same time)