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what’s the word? 

A word used a lot in Boston, Massachusetts.

It’s basically saying what’s happening?, or what are the plans for today.

(In texting- “wtw”)
Friend 1:“Yo, I got a free crib what’s the word?”

Friend 2: “Ight word, I’m boutta swing thru with the budand the rollies”

Friend 1: “Bet”

what's up with that

A phrase used to ask about something odd, or what the point of something is. The word "that" can also be replaced with whatever noun the person is asking about. It is also common to inerject the word "fuck" into the phrase to express shock or discust.
What's up with the smirk?
Look at all those bags on the road. What's up with that?

Person1: What the fuck's up with your hand!?
Person2: Ahh! Why are you just standing there?! Take me to the fucking hospital!
what's up with that by Cinymin86 November 16, 2009

what's poppin'

So if u ask someone "What's poppin' with you". You are asking what is good with that person or what are they doing.
what's poppin' by Ohmod Logan June 23, 2006

what's his nuts 

A phrase used generally to replace the name of someone when you have forgotten who you were going to talk about. This is similar to What's his face? or What's her face?, but usually catches the other person off guard.
Guy 1: So what are you doing for Labor Day this year?
Guy 2: Oh you know, I'm going home to play a game of football with what's his nuts, the guy who always ran an extra mile after gym practice.
what's his nuts by 403forbidden September 3, 2006

what's your damage? 

A sarcastic way of asking someone about the mood they're in. Was coined in the 1988 teen drama, Heathers.
From Heathers (1988):

Heather Chandler: What's your damage? Brad says you're being a real *kuse*.
Veronic Sawyer: Heather, I feel really sick, like I'm gonna throw up, so can we please jam now?
what's your damage? by Tommyt August 28, 2005

What's the F? 

It means you asking someone what is the temperature outside or inside. Can be "What's the C" for Celsius areas. (Or even K, if you wanted.)

Response ends with the actual temp. but you just say the number and 'F' at the end.
Dave: Hey dude what's the F?
Steve: It's 75 F.
What's the F? by ArctixFawx June 17, 2011