A person who uses meth and staying awake for days at a time thinks their focused on there project usually something they think they can repair but in reallity they end up breaking it so the parts end up in a box with all the other tweaker parts
He has been up for days tweaking on electronic items , and hasnt fixed any of them , all he has now is a bunch of parts, he is such a tweaker.
by Kimberly Delgado July 10, 2006
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Typically someone who smokes/snorts/does meth. Some people who have tweaker habits but don't do meth may also be referred to as a tweaker. People who are constantly touching their face, or looking around like they think someone is watching. A tweaker can typically be one of two kinds. Either very loud, weird, unusually happy about everything (or sometimes even angry) and is that "in your face" kind of person. Or that guy sitting at the back of the bus with his hood on staring at everyone nervously because he thinks they all know he's high.
A tweaker downtown today tried to sell me meth! Can you believe that?
by LiaMiaLoshia December 11, 2014
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Tweaker is tayisa, someone who's a hoe
Look at that hoe Tayisa, she's a tweaker
by Angie08 May 9, 2017
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Mainly used in Philadelphia, A Tweaker is a female who gets around! A whore, smut, slut, hoe, or trick. "Tweak" can also be used in it's place, as well as "Tweaking"
Yo bul?

"Wassup with you bul?"

Shit!...whats up with Kaneisha and them?

"I don't know.....but I def heard her squad is some tweakers!"

Oh yea?.....they tweakin?

"That's What I Heard!"
by mickey futuristic February 19, 2010
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A people who uses the drug methamphetamine. A low life piece of shit. Someone who will steal from you in order to score meth. Zombie like
I was watching the video "tweakers" by skinny mumbles on YouTube.

The tweaker beater mafia is coming to town to get rid of our cities meth problem.
by DirtyGiggles February 28, 2012
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A low life piece of shit who feens hard for meth and other drugs and cant keep their shit together
"You see that guy over there?"
"Yeah! What's he doing with that air duster?"
"Idk think hes a tweaker"
by HelpFul Definitions November 9, 2015
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Your girl is a tweaker everyone bust her ass
by jkgggk September 16, 2009
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