Someone who likes to adjust or fine-tune things; a person who makes small changes to an existing object in order to make it better or to suit one’s preferences
Tessa is known as the Tweaker in her social circle for her knack of turning old fabrics into fashion-forward apparels.
by fln September 23, 2013
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Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
by briight April 06, 2010
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A Noun. A GIRL OR BOYTHAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO PRACTICALLY THE WHOLE NEIGHBORHOOD.

A Noun. A GIRL OR BOY THAT IS KNOWN FOR SLEEPING WITH OR GIVES ORAL SEX TO NUMBERS OF PERSONS THROUGHOUT THE CITY.

TWEAKER IS USUALLY USED TOWARDS FEMALES, BUT IT IS NOT UNCOMMON TO USE IT TOWARD A MALE. BOYS ARE USUALLY CALLED THE "BURNING BOYS", THE EQUIVALENT OF "TWEAKER".
*SEE "BURNING" 2nd and 3rd definitions...*
JESSICA SIMPSON SLEPT WITH KIM KARDASHIAN'S BOYFRIEND REGGIE BUSH.

KIM -"Jessica slept with my boyfriend, and I heard that she slept with Common, Kanye, and Usher, and gave Ray J, and Nick Cannon oral sex,... She is a TWEAKER!!!"
by ANCIENTCHINESESECRET93 May 18, 2010
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Someone who Messes around with more than one person.
Christina had sex 5 Guys Last Night. She is Such A Tweaker!
by Mizzjas1802 October 13, 2010
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Someone who gets lit all the time
Look at Jailen over there he’s a young tweaker
by Yvng South January 29, 2018
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1. A man who pretends to be your friend but steals from you when your back is turned. Also will be fronted large amounts of methamphetamine then skip out on the bill because you hurt his feelings when calling him out on his own shit.
2. See also Jake Place or "little bitch"
"Dude did you hear that Kristi lost her house? It's all because of that Tweaker scum who stole her shit and never paid her back. Man he really Jake Placed her ass."
by GotohellJake December 05, 2014
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