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What's up with it

What's up, or how's it going, often a phrase used by cool people
Joe: What's up with it?
Bob: Oh, nothing really, just hanging out at
by Court2010 October 2, 2008
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What's Up

An extremely annoying phrase used by people who have never heard of "hello." Usually people ask this when they are bored, expecting the person they're asking to entertain them.
Guy: what's up?
other guy: *sigh* stop trying to make me entertain you.
by The Ironic Geek September 27, 2015
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two's up

two's up is the act of slipping one in a lady friend whilst your friend does the same on another orifice
i know it's a sunday but there's two's up on the cards... let's GO!
by nick williams January 13, 2009
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2's up

The gang sign of Del Paso Heights. Also a song by Lil Darrion & TreSolid, which is about DPH. If you throw up 2's in the wrong neighborhood or around the wrong people, you'll probably get shot.
TreSolid: "I told then bitches 2's up"
by AngOfwgkta June 13, 2016
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[what's up you mother fucks]

a way to address a room full of people, in a public and/or private place, perhaps after one of those " i just don't give a shit" days.
scene: walking into the break room after you've realized the last 4 hours you've been working have produced nothing but shit.

enter room:
person 1: hey bill whats going on
person 2: bill, BILL, billy boy!
person 3: hey billy

bill: (mumbles) yeah um hum... WHAT'S UP YOU MOTHER FUCKS! hows your day asshole? Mine's turned to shit how about that? :promply walk to the vending machine grab your snack in the midst of the silence and go outside to smoke:
by jadiepoetatie December 9, 2008
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What's Up?

1) The words that pop out of human's mouths when they desire to talk to you, but don't have the intelligence to think of something intelligent to say.
2) The words people say when they haven't taken a science class to realize that the sky is above them.
3) The words people say when they strongly desire to hear the response "nothing" or "not much".
4) The words people say when they are trying to make friends/trying to keep a friendship, but utterly failing.

Next time someone says these words to you, ask them which of the above was their purpose for saying it.
"What's Up?"
"The amount of lives that have lost hope in this lost universe! OH THAT SOME ONE WOULD STAND UP AGAINST THE TERROR THAT IS SURMOUNTING IN OUR INSURPASSABLE--"
"K seeya!"
by livinhopie May 29, 2018
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It's up your ass

Your friend where is it?
it's up your ass!
by It's up your ass! September 26, 2018
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