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A nube tube is an under barrel mounted granade lancher use in the Call Of Duty games. They are called nube tubes because they are easy to kill with and typically only new people use them.
DUDE! Grenade out of no where?!?! NOOB TUBE!!!

Noob Tuber 

Arlo Cash Halloran, or some noob who is REALLY bad at Call of Duty and uses a grenade launcher ALL THE TIME to get kills. Definition of annoying.
Damian: O MY GOD I GOT KILLED.

Harriet: By who?

Damian: A noob tuber...
Noob Tuber by Blake Liberi March 4, 2014
The Grenade Launcher attachment for all Assault Rifles (Except MP44) in Call of Duty 4: Modern Warfare.
Noob Tube by Fertro June 2, 2008
gay expression used by people in call of duty when they are tremendously embarassed by getting owned by a grendade launcher. If you get jealous, use it urself retard
When somebody in cod gets embarassed about getting shot by a grenade launcher, they get jealous and start to make fun of the person who owned them by saying "NOOB TUBE!"
noob tube by bluedevils1206 December 22, 2009
Noun.
Despite many saying that this is something specific to Call Of Duty 4 it is in fact a general term for any weapon that is cheap and/or over-powered in any video or computer game, usually a grenade launcher or RPG but also, especially with newer games, can be a shotgun (i.e. Call Of Duty, Half-Life 2, Rainbow 6) at least when up close. Use of it is commonly frowned upon unless used with some finesse or tactical forethought.
Ex.1
Tom: "Dude, I was playing Halo 3 the other day some dude unloaded on me with the Mini-Gun."
Harry: " The Mini-Gun is such a Noob Tube"

Ex.2
Dick: "Gosh that guy just shot me with a Noob Tube."
Tom: "What a Noobish thing to do!"
Noob Tube by Xynocron August 9, 2009
A grenade launcher on modern warfare 1,2 that only douche bags and people with no skill use. They may only be used if you are trying to unlock the attachable shotgun.
That little shit just noob tubed me, what a douche
Noob Tube by Jon jane February 15, 2010