A person who is addicted to crystal meth and undergoes great changes in personality and appearance. The biggest populations are in small towns and rural areas. The drug is incredibly cheap and easy to manufacture, so no matter where you live there is probably at least 3-4 residents in your neighborhood making it in their garage.

There are a few very easy ways to spot a tweeker.

1. Very skinny, with especially gaunt faces
2. Complete disregard for appearance. They will have dirty clothes, be unshaven, messy hair, no makeup.

3. Appear to be much older than they actually are.
4. Brown teeth, often with many missing.

5. They have red sores all over themselves, this is from picking at their skin while high.
6. They are generally very paranoid and confused.

You can see them anywhere, in a small town it's not uncommon to see a dozen in the course of a day. Generally avoid them and don't give them the impression that you have anything of value. If you see them in a retail store, they are almost 100% guaranteed to steal something.

It's a sad transition, and almost always their journey ends in prison or death.
Drive to the oldest, shadiest area of your town and observe the people walking around, you will spot some tweekers almost immediately.
by Maximillian Van Der Mann January 23, 2011
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Those who indulge themselves with Methamphetamine until they become very paranoid and develop a serious case of body tremor.
eg. People who ask for money on a daily basis; people who consistently and rapidly scratch themselves. "Hey check those tweekers arguing with the cops, the one on the left looks all messed up."

eg. Tyrone Biggums from the "Chappelle Show"; Jake Mazursky from "Alpha Dog"; Every character in the movie Spun; That chick from Full House, in real life.
by Romero Diaz June 22, 2008
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A person who over indulges when taking psycho - stimulants, such as Adderall and crystal meth. Many become habitual users... meaning they leave less time in between each "run" so their brain never fully recovers like it did when it was just every now and then. Most brain damage, hallucinations, delusion, paranoia, anorexia, etc... is unlikely due to amphetamines alone. Tweekers don't sleep or eat. They can't continue to function. Tweekers lose their sense of Reality. Tweekers lie about everything, only because of how DEEP their self hate runs. Tweekers are sad that they are tweekers but see no point in quitting after so many years of frying their brain, losing loved ones, self pity, regrets, the list goes on forever. Just because you have " tweeked " once in a great moon doesn't make you a "tweeker" . But tweekers are Perma-tweeked.
The shy girl next door with the obvious lack of self-esteem tweeked on meth only twice last year. She was beautiful and had a great fashion sense. Now that she moved in with her dealer boyfriend. She started tweeking everyday, nonstop. In less than 6 month she lost her job, account, money, one tooth. And she was beautiful but 6 month of being a tweeket aged her, visually, 6 years. She's literally skin and bones with no muscle tone. I don't hate tweekers because I can alway see and smell one within 50 ft of me, so I don't associate with them because if you do... you can only blame YOU for being stupid enough to position a tweeker to burn you. They lie, steal, cheat, and believe most the lies. Stay away
by CamCordChic January 1, 2017
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a person who does meth or other hard chemical drugs
by marsi March 30, 2005
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Someone who steals from others in order to produce the funds to get high.
Hey man, never let Jimmy into your house! He's a notorious tweeker !
by 420 Boy February 4, 2018
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