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The Holy Hand Grenade of Antioch 

A Reading from the Book of Armaments, Chapter 4, Verses 16 to 20:

Then did he raise on high the Holy Hand Grenade of Antioch, saying, "Bless this, O Lord, that with it thou mayst blow thine enemies to tiny bits, in thy mercy." And the people did rejoice and did feast upon the lambs and toads and tree-sloths and fruit-bats and orangutans and breakfast cereals ... Now did the Lord say, "First thou pullest the Holy Pin. Then thou must count to three. Three shall be the number of the counting and the number of the counting shall be three. Four shalt thou not count, neither shalt thou count two, excepting that thou then proceedeth to three. Five is right out. Once the number three, being the number of the counting, be reached, then lobbest thou the Holy Hand Grenade in the direction of thine foe, who, being naughty in my sight, shall snuff it."
King Arthur: Right. One... two... five.
Galahad: Three, sir.
King Arthur: Three.
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Irish Hand Grenade 

A mixed drink typically drunk on St. Patrick's Day, made and drunk like so.
1. Fill a pint glass halfway with a stout such as Guiness.
2. Fill two shot glasses, one with Irish cream such as Baileys and one with Irish whiskey such as Jameson and set them both inside the top of the glass so that they wedge against each other.
3. Pull out the shot of Irish whiskey like you would the pin of a hand grenade and down the shot. The shot of Irish cream will fall in to the stout. Down that next.
"Sure do love these Irish Hand Grenades. Just wish it wasn't so fucking awkward."
Irish Hand Grenade by Aelle February 6, 2019

Hillbilly hand grenade 

An act of road rage in which a chewing tobacco user hurls an open canister "usually a soda bottle" full of aged, rancid tobacco spit at a fellow motorist, cyclist or pedestrian
Some asshole cut me off on the way to work so I chucked a hillbilly hand grenade into his open window.
Hillbilly hand grenade by GoinHAM December 11, 2013

Peruvian Hand Grenade 

The act of farting into an empty gatorade bottle (or container with similar liquid volume capacity), capping it, and tossing it to a friend (or foe), for him (or her) to later open and be greeted with the gift that keeps on giving...flatulence.
"Oh my god, bro. Why did you tell me to open that, it was foul!"
"Don't be scared, girl, it's just the ol' Peruvian Hand Grenade."

Tim Allen’s Hand Grenade 

The act of nutting and having it french kissed into your ass while yelling “It’s Tool Time!”
Hey I heard some slut French kissed Aden’s nut up his ass, she gave him Tim Allen’s Hand Grenade

Holy Hand Grenade 

1) Monty Python: A hand grenade forged to smite the powers of evil. Instructions: Pull pin, count to three, throw.

2) Worms: MOST POWERFUL WEAPON EVER. Or at least the coolest. A parody of the Monty Python weapon, the holy hand grenade is an awesome weapon which shouldn't be reckoned with.
1)And Saint Attila raised the hand grenade up on high,
saying, 'Oh, Lord, bless this thy hand grenade that with it thou
mayest blow thy enemies to tiny bits, in thy mercy.' And the Lord
did grin, and people did feast upon the lambs, and sloths, and
carp, and anchovies, and orangutans, and breakfast cereals, and
fruit bats, and large...

2) wURmz_Masta: i totly pwned u wit tht holy hand grenade. haha
Holy Hand Grenade by Lyrax February 25, 2005

Southern Maryland Hand Grenade 

term referring to 10 oz Budweiser cans in Southern Maryland, all can beer can be referred to as such but 10 oz bud is the preferred version
The party seemed over until Buddy showed up with a case of Southern Maryland Hand Grenades.