big oof 

what tumblr girls say in response to anything you say; usually something negative that they don’t know how to respond to.

“yeah dude my cat got diagnosed with cancer”
“big oof my guy”

big oof by dino.cogs October 16, 2019

Big OOF 

The worst type of work. Motivation ist instantly lost

My new assignement? Big OOF.

Big OOF by John Treehouse February 6, 2021

Big oof 

Something unfortunate that happened. "Oof" comes from a Roblox sound.

Guy 1: I wanna to get some ice cream for my 5th grade graduation.
Guy 2: The ice cream shop is closed.
Guy 1: Man, that's a big oof!

Big oof by littlemew June 1, 2021

Big Oof Nibba

A particularly strong or annoying enemy in a singleplayer video game, typically a boss or other non-recurring entity.

Guy playing video games: "God, this boss has killed me like ten times now!!"

Guy's friend: "That's a Big Oof Nibba right there. Sorry, man"

Big Oof Nibba by captconan June 4, 2018

BIG OOF moment 

When something is a very melodramatic and a combination with collosal oof and oof

Me: I've heard that you got scammed in Steam

Friend: Yeah man :(

Me: BIG OOF Moment

BIG OOF moment by The Lag Guy March 23, 2020

The Big Oof 

Death.

George Washington took the big oof on December 14, 1799

The Big Oof by PopeGod March 14, 2018

The Big Oof 

Cancer, Usually transferred through memes

Yesterday i caught The Big Oof.

The Big Oof by Thanos March 4, 2019