Tweak

a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
You might act a little crazy when you tweak, but you'll come down in a minute or two.
by Lady Artemis April 03, 2010
Get the Tweak mug.

Tweak

Street name for vitamin b6. AKA hack/beesicks. Commonly used for assisting the consumer in having a lucid dream.
Jordan hooked me up with some tweak, it was dope.
by Michael November 23, 2004
Get the Tweak mug.

Tweak

People that love to have sex. Someone whose always horny.
YO I HEARD SHAWTY RITE DERE A TWEAK!
by robbyfhark July 29, 2010
Get the Tweak mug.

Tweak

someone who's bugging out from tina... (crystal meth)
by sfmar May 02, 2005
Get the Tweak mug.

Tweak

To drink obsurd amounts of whiskey, vodka and beer....then throw a entire bottle of hot sauce about a residence room and in a couple peoples eyes, then passout and have a seizure in the middle of the kitchen....decent
Kevin Tweaked and emptied a bottle of hot sauce about the room
by Tweaksauce May 14, 2010
Get the Tweak mug.

Tweak

(Verb) To experience the speedy, lifted, euphoric effects of the drug Adderall or generic Adderall. NOT to be confused with the "half-tweaked" or "zombie" state experienced by those who take it too often (marked by indifference, and a strange respiratory effect in some that produces a "Hkkekkuuhehkk" sound upon trying to sleep).
"Dude, I just wrote five pages in a half hour."
"Man, you're tweaking!"
"This is awesome!!"
"Don't turn into a zombie - you'd piss everyone off and make weird 'Hkk' noises.. like someone we know!"
"Yeah, I love tweaking, not half-tweaking!"
by KingOfOranges June 02, 2013
Get the Tweak mug.

Tweak

To Bone; Bonk; Do so on and so forth, but only with an ex-girlfriend. Not to be confused with regular sex.
"Went out last week and ended up tweak-in our ex"
by Dobern July 21, 2004
Get the Tweak mug.