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Diffy in the jiffy 

Used commonly as slang in the modern videogame League of Legends, popularized by a Twitch streamer Tarzaned and many others, when one of the players in one of 4 lanes (Botlane, Midlane, Toplane, and Jungle) hardly underperforms in the Jungle role or gets outplayed by the enemy player several times, causing the game to be lost before 20-minute margin.
Yassou: Oh no! We have Nightblue3 on our team
Sanchovies: Diffy in the Jiffy it is...
Diffy in the jiffy by Chrive May 29, 2020
Mathemtician Slang:

A differemtial Equation.
Yo son, did you use the Wronskian on that mutha fuckin' ass diffy-q?
diffy-q by Skandal Jack May 13, 2005
Mathematician slang for differential equation.
Doood! Diffy-q's are suck!

Translation: I'm stupid.
diffy-q by meselfs January 11, 2005

diffy in the miffy 

When someone can't hang
I challenged some fools at a Party to a round of Beer Pong and they started started throwing up after the first 5 cups.
Huge diffy in the miffy!
diffy in the miffy by Aehrre January 30, 2022

diffy screw 

differential equations - the midway point in mathematics for most modern engineers
Once you're done with calc useless, you can take diffy screw
diffy screw by mouffpiece May 12, 2016

Diffy Gravy 

- Matthew just hit 1 million subscribers!
- Oh, nice! He is diffy gravy!
Diffy Gravy by sennx_ February 14, 2022