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The term "homie" was started by Mexican-Americans, most commonly in East Los Angeles, though, of course, the credit givin for the term goes out mostly to African-Americans. The term derrives from Homeboy, and was shortened down to just "Homes" or sometimes spelled "holmes", which is another Mexican-American term, commonly used in California. Rapper Biggy Smalls has used the term homes/Holmes commonly.
Person 1: Whats happenning homie
Person 1: just chilling homes.
Homie by Eddie.P March 31, 2007
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Today I wrote a letter to the hudge for my homie
Homie by Ddubsgirl July 16, 2018
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Contrary to popular belief, it was the Chicanos aka Mexican-American Pachuos of Los Angeles who created words such as Homie, Homeboy, and Homes which were all derived from their slang known as "Calo". However, Blacks adopted it and there's people who still think they created it just like they think they created Lowriders and call California "Cali" when the Pachucos did that.
Pachuco #1: What's happenin homie?

Pachuco #2: Just kickin it homes.
Homie by rob-g April 20, 2007
Homie

Slang for friend.

Homie may also a derivative of "Homi/Homo."

"Homo" is latin for "human being."
"Whats up my homie."

Can also mean "Whats up my (fellow human being)."
Homie by Bolasdagrk November 13, 2018
A term that now refers to a close friend. Historically, it was once used to called friends who would come to your house and smoke some weed. Hence, your "homie."
Wassup homie?! Let's pimp some ho's.
homie by Dr. Philip January 29, 2003
1. table partner (in school)

2. lab partner
Mrs. Martin: For this lab, you will work with your homie and another pair of homies.
Homie #1: Let's work with those homies, homie.
Homie#2: Yes, those look like good homies to work with.
homie by silly teenage boy February 12, 2017
Daniel Skomorovsky and Elmo
DANIEL AND ELMO ARE HOMIE AF
Homie by WhyAreUGay May 1, 2019