Unlike son of a bitch which is in reference to ones canine mother, son of a motherfucker is in reference to ones father that it is assumed was a motherfucker.
Can also be used as a curse when frustrated or infuriated by something.
Ask Doug?! Why, I wouldn't trust that son of a motherfucker as far as I could throw him.
What is wrong with this goddamn remote?! Son of a motherfucker!
After spilling your cereal all over the floor:
Oh, man. Son of a motherfucker! Shit!
Billy J. His name alone tells you he is, was, and always will be one of the realest motherfuckers there ever was. Billy the realest motherfucker who everwas,gives nofucks about motherfucker who wasn't. He has been said to have told Chuck Noris to his face he looked like a fake motherfucker and walked away unscathed.
A person who would proudly call themselves a “gamer”. This person would typically shower once a week or every two weeks and their hands will be crusted with Cheeto dust at all times. This person would also smell like shit and live with their parents. They’ll also have greasy hair 24/7 despite any annual showers because you just can’t wash that shit off. When they travel in groups they are referred to as “a bag of Cheetos”