When you are so overcome with the feeling of being as awesome as Ziggy that you can't control yourself!
Damn Felicia, that bitch twerking so hard she must have Ziggitis!
by Silky mane May 7, 2016
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Used when someone gets the plot of Family Guy incorrect. Even if it's opinionated.
Ziggity Zowie! Brian isn't straight, he's gay with Stewie!
by Lino Dolphin January 24, 2022
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