When you beat someone in any type of situation. Also an exclaimation when you beat the shit out of some asshole. Or when a situation is just outta hand and you don't want to deal with it anymore.
Give it up bitch, game over.
GAME OVER MOTHER FUCKER!
This is game over for me, I'm out.
by grrrinator October 28, 2004
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Phrase used to describe one who has consumed far too much liquor and is therefore reduced to a drooling, snoring, unconcious lump who may or may not end up vomiting on themselves or other people later on in the evening. May sometimes lead to boot and rally, pissing in the fridge, or other drunken acts which will undoubtedly not be remembered in the morning. See ptfo. This is the most opportune time to attempt such daring feats such as teabagging, giving a flying squirrel or other humiliating acts.
Dude, check nick out, Game over.
Woah, did nick just boot-n-rally? i thought it was game over! add another tick to the boot-n-rally tally.
by Ry-Lo September 17, 2007
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when the act of slipping or falling results in fatal or severe bodily harm
dude my brother had a game over in the shower.
omg how?
he totally slipped on the soap and broke his leg.
by NRHsteezy March 5, 2008
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When someone's dead, or too messed up to go on living a normal life.
-You hear about Eddie?
-Yeah I heard he od'ed on some bad coke.
-It's game over man.
by david k February 28, 2005
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everyone in the world is playin 'the game'

if you think about 'the game' you lose 'the game'

therefore for readin this explanation you are all losing the game!!
hey!
hi!
guess wat?
wat?
GAME OVER
awww shit im losing the game now cuz im thinking bout it thanks
no problem

by hula hoop June 2, 2007
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when the party is o-v-e-r. Because you've run out of stuff or run out of money; because its Monday morning; because you're goin' down; because its Day 3; because everyone else left hours ago; because the wife/husband/g-f/b-f is pissed; because its interfering with your ability to have sex, etc etc etc.
Dude, its 6:45 a.m. and you have to be at work at 7! Put down the pipe, game over already!
by brooklyn516 September 20, 2004
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