1. Toe up is a term made popular in the teen dramady, "Clueless." Dione says that Ty is "... toe up; our stock would plummet." Meaning that Ty is lousy and useless, not to mention detrimental to social status. 2. Also can be taken as "upside down."
1. That guy is toe-up. Don't hang with him.
2. I was so toe-up for Paul, I can't believe he likes Shelly instead.
Slang for getting a women getting some Sexual intercourse, Thus getting put on her back to be "toe up" (Mainly from The South of North America) feats. in a track on Outkast's album - Stankonia