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Apparently a drug used to treat type 2 diabetes to produce more insulin as those with type 2 diabetes don't produce enough insulin or their bodies don't respond to insulin very well.

It is now being used by celebrities to lose weight, and it makes them look awful.
Have you seen Meghan Trainor after using Ozempic? She used to be so hot, and now she is ugly. 💔🥀
Ozempic by UltimateDoge November 17, 2025
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An unflattering term of disparagement for people who are too skinny, whether or not they use ozempic or not.
She looks ozempic, no curves, no muscle, gaunt face and scrawny body, way too ozempic.
Ozempic by Sheilee August 17, 2025

Ozempic face 

A a term used to describe the sagging, gaunt look of the facial skin due to the loss of facial fat following drastic weight loss from the drug Ozempic.

Ozempic treats type 2 diabetics and obesity. Due to its side effects (glycemic control, shitting your brains out due to diarrhea, extreme bloating) people without these conditions are using it for its ability to induce weight loss, making it popular amongst celebrities and anyone who wants a quick fix. This has caused the price of the medication, and its sister drugs, Wegovy and Rybelsus, to skyrocket and experience limited supply, making it difficult for users who legitimately need them.
I hadn’t seen him until this afternoon and the Ozempic face and butt surprised me. I miss his old butt. It was a fine ass, as they say. Sad day…
Ozempic face by Sickomonster September 17, 2023

Ozempic Olympics

The Newest Weight Loss Competition in Hollywood whereby Women, or them/they’s (even not Obese ones) take Ozempic for quick weight loss and immediately lose their Ass and their face sags, looks gaunt and they look as though they’ve aged 5+ years overnight! But they act as if everything is normal AF!
“O” gathered all her wealthy gal pals together to eat cake and talk Ozempic Olympics 90 mph to work calories of cake off after…as if!
Ozempic Olympics by Judalon1952 January 20, 2024

ozempic hedge 

when you date or attempt to date a high calorie individual (typically a girl) because you see the potential if they lost weight
i would lowkey hit becky
bro her bmi is room temp
ozempic hedge bro

ozempic hedge 

when you date or attempt to date a high calorie individual (typically a girl) because you see the potential if they lost weight
i would lowkey hit becky
hell nah, her bmi is room temp
ozempic hedge bro

Ozempic economy 

As the overweight move from Golden Corral to Ozembic restaurants are feeling the economic thinning as well.
That Taco Bell down the street was just taken out by the Ozempic economy. I'm gonna miss the cinnamon crispas.
Ozempic economy by jmacofearth July 29, 2024