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"Jagoff" (sometimes "jag-off") seems to have originated in Pittsburgh but is also recognized in the Midwest as slang for an inept, feckless, contemptible, or generally worthless person, a loser, a "schlemiel."

The term is almost certainly derived from the verb "jack off" (through noun "jack-off") as in "masturbate," but somewhat like the British use of "wanker," it is usually not a direct comment on self-pleasuring, but more of a general term of contempt or deliberate abuse. Like "wanker," "jagoff" is somewhat vulgar and not to be used lightly, and avoided in cultivated speech, but is recognized by all in the regions in which it has currency.

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The book KILLER CLOWN relates that John Wayne Gacy became especially flustered or angry when called a "jagoff." So the police deliberately used that term to throw him off-balance during interrogation.

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jagoff by al-in-chgo August 18, 2010
Jagoff- 1.Famous word used by Joe Pesci in the film "Casino". 2. A word used by Italians or North Eastern Americans to describe a Jackass or a Jerkoff. 3. A stupid fucking oaf.
That fucking lazy jagoff just stole my toast from the breakfast table.
jagoff by Master JP March 24, 2004
Go back ta da nortside ya jagoff.
jagoff by southsidesmitty September 25, 2004
People who cut off people in traffic are jagoffs.
Jagoff by Jim Bob September 12, 2003
Coach Cal: "You must be from Western PA. Where you from?"

Buccigross: "Pittsburgh."

Coach Cal: "OK, so basically you're a jagoff."
Jagoff by SH622 January 26, 2010
one who performs annoying or irrtating but ultimately benign actions.
He took food from my fridge again: he's such a jagoff!
Jagoff by Minkus June 25, 2003