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A common alternative to slang term fosho, meaning for-sure.
A: Yo, while you're at the store grab me a 40.
B: Aight, fofo.
fofo by The Nig who Nogs August 29, 2010
FoFO:Friends on Facebook Only; people with whom you have no contact other than on Facebook.
I haven't seen Betty since high school. We are FoFO.
FoFO by TooSick4U January 15, 2011
Standardised teaching term protocol.
Acronym for:

"Fuck Off (and) Find Out."
Student: What the hell do these errors mean?!
Lecturer: FOFO.
Student: What the fuck?! ::walks off and grumbles about sarcastic lecturers::
FOFO by Phyre February 28, 2005
Ur such a fofo! That piece of shit fofo just failed me!
fofo by Cainesterzz25 January 30, 2008
1. Short for father-fucker... I believed I had one of these all through my childhood... I was probably right. Unbelieveably strict and bitchy person... you don't want to live with one.
2. Mother (or anyone else who fucks father constantly)
'You fofo!'
'Yep, my mom's a real fofo. Condoms are always on her grocery list.'
fofo by Anonymous Weirdo July 24, 2004
A nick name for the foreskin found around the head of an uncircumcised penis. Often used around younger children or people embarrassed to say foreskin. Common usage among Americanized Hispanic, Asian and Mixed race children.
Mommy, Why do I have a Fofo and daddy doesn't?? Or You have to pull back the Fofo to clean around the head.
Fofo by CSpotRn August 6, 2010