A daily web comic found on the website explosm.com. The comic writers are 4 comic artists named Rob, Kris, Dave, and Matt. Each artist has his own sense of humor; like Rob and Dave's comics having a genuine sense of humor, while Matt's tend to focus around AIDS and sex, and Kris's comics are usually about someone dying or missing limbs. The web comic also has a dozen or so animated shorts.
guy 1: Man, Cyanide and Happiness is a great web comic!
guy 2: Hey, I've never heard of it.
guy 1: You should check it out sometime. It's really funny.
guy 2: Ok I will.
"Do you like the comic Cyanide and Happiness?"
"Yeah, it's pretty funny, sorta sexual, a little depressing."
"Like urban dictionary?"
"Pretty much the embodiment of urban dictionary"
Usually said simply as Cyanide and Happiness, and sometimes misspelled "Cynaide and Happiness", a webcomic hosted at explosm.net. Recurring themes involve necrophilia, rape, illness (Cancer, AIDS), pedophilia, and poking fun and Christianity's Jesus of Nazareth (All in good fun, of course). Recurring "characters" include "LOL Fag!" man, Punchline Spoiler man, et cetra. The series (with updates every day, on most occasions) is most prominent for its black comedy.
Cyanide & Happiness happens to be the only webcomic I really find amusing; opinions vary, of course.