the "Little Blue Box" is used to refer to the TARDIS, the Doctor's time-traveling spaceship in the BBC show "Doctor Who". The show, the longest running television show, is one of the most popular shows in the United Kingdom, and is also popular world wide. TARDIS, or Time And Relative Dimensions In Space, is how the Doctor is able to travel through the universe. To people who do not know of the Doctor and see TARDIS, since it is disguised as a police box, call it a "little blue box".
Donna: You really believe in all that stuff, don't you?
Grand dad: It's all over the place these days. If I wait here long enough . . .
Donna: I don't suppose you've seen a little blue box?
Grand dad: Is that slang for something?
Donna: No, I mean it. If you ever see a little blue box flying out there in the sky, you shout for me Gramps. Oh, you just shout.
A condition, similar to blueballs but applicable to women, in which the genital area is flooded with blood for so long without release that it becomes painful. Can be both a noun and a verb, and used literally or figureatively.
"I was totally going to do it with this guy last night, and we were all making out and what not, then he left, and now I've got a nasty case of bluebox."
"Considering the way the White house owns Congress right now, Harriet Miers is gonna feel totally blueboxed if she doesn't get confirmed."