When somebody says something really stupid,OMG ISS is what you should reply with. It stands for OH MY GOD. I'M SO SURE!
by Sosure March 24, 2010

by couchdute September 21, 2009

Oh My Goddess! Used in the same context as "oh my God" but as an alternative for those of us that seek another path
by The Lady Rowan July 2, 2012

by omgarmyonces May 14, 2020

This is a room in everybody's house where they keep the door closed because this is where they put all their junk that they don't know what else to do with it. So when you open the door the only thing you can say is "Oh My God".
Friend#1:What's behind that door?
Friend#2:Oh that's my OMG room.
Friend#1:Well let's have a look.
Friend#2:OK
Friend#1:Oh My God!
Friend#2:Oh that's my OMG room.
Friend#1:Well let's have a look.
Friend#2:OK
Friend#1:Oh My God!
by Mojo maniac October 6, 2008

OH MY GOD NO TOILET PAPER!
The horrifying realization there is no toilet paper after a significant bowel movement.
The horrifying realization there is no toilet paper after a significant bowel movement.
by dintx August 22, 2010

by Baylien Culture December 22, 2021
