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A 'speed'/'crystalmeth' freak.
Tweaker's are 'tripped out' addicts who live for 'gas'/'ice' and party for days with no concept of time or the outside world.
"Val Kilmer play's his best role ever as a hardcore tweaker, a crystalmeth freak, in a great movie called 'The Salton Sea'."
tweaker by Diego August 18, 2003

tweakerlips 

Asshole tweaker that wont shut his face picking mouth.

Tweaker that smokes from pipe to the extent that his lips turn blue.

Normal person with a cold sore on thier mouth.
"Shut your fucking face tweakerlips"!
tweakerlips by kfools September 29, 2009

tweaker sneaker 

The shoes worn by meth heads, but the term could be broadened to include junkies or crackheads. Ugly, blocky, generic white shoes with tattered shoe laces that look like the tweaker barely even bothered to tie them. Tweaker sneakers are covered in dirt and various bodily fluids.
Get some new shoes you bummy lookin' motherfucker! Those kicks look like tweaker sneakers!
tweaker sneaker by money mike 305 November 6, 2009
A person who uses meth and staying awake for days at a time thinks their focused on there project usually something they think they can repair but in reallity they end up breaking it so the parts end up in a box with all the other tweaker parts
He has been up for days tweaking on electronic items , and hasnt fixed any of them , all he has now is a bunch of parts, he is such a tweaker.
Tweaker by Kimberly Delgado July 10, 2006
Typically someone who smokes/snorts/does meth. Some people who have tweaker habits but don't do meth may also be referred to as a tweaker. People who are constantly touching their face, or looking around like they think someone is watching. A tweaker can typically be one of two kinds. Either very loud, weird, unusually happy about everything (or sometimes even angry) and is that "in your face" kind of person. Or that guy sitting at the back of the bus with his hood on staring at everyone nervously because he thinks they all know he's high.
A tweaker downtown today tried to sell me meth! Can you believe that?
Tweaker by LiaMiaLoshia December 12, 2014

Tweaker Neck Syndrome 

Is a orthopedic disease tweaker arthritis caused when someone smokes meth amphetamine and holds their head in a tucked position to one side . This is usually followed by a popping of the neck to attempt to alleviate a cramped neck. Usually tweaker Olympics or chair Olympics ensue. Where the tweaker pops his knuckles and back compulsively. You could end up dislocating your hip or slipping a disk.
Todd is suffering from Tweaker Neck Syndrome. After hitting the pipe he started to pull a crack head twisting his head to produce a cracking sound. Then he preceded to twist his body from the waist to crack his back.