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Game Grumps 

A let’s play YouTube channel staring Arin “Egoraptor” Hanson and Danny “Sexbang” Avidan. Their episodes often involving silly voices, jokes, running gags, making fun of games (typically Sonic the Hedgehog) and insightful advice and life stories. Also shows by the name of Steam Train, Grumpcade and Steam Rolled appear in the channel, although not as frequent, it is also expected for the channel to have various random segments every now and then.
Do you watch Game Grumps?
Who?
You know the let’s play duo involving that one animator and musician?
Nope.
The two dudes who could be in a Pantene commercial .
OH, GAME GRUMPS

game of life 

A drinking game in which players must deform their drinks to survive.

If one player says to another "game of life", the player spoken to must either immediately finish their drink or display the damage on the container that they are drinking from (such as a dented beer can or a solo cup with a broken rim). If the player spoken to can sport a deformed vessel, the player that called them out must finish their drink.
Player 1: "Game of life, bitch!"
Player 2: "Awww man you got me, I forgot to put a dent in my can!"
*Player 2 finishes their beer*
game of life by jfriedly September 11, 2013

game ended 

"I just game ended my stupid ex-wife."

game blouses

a game ending taunt dished out by the winning team in any competition, usually when the final winning blow occurs. It originated on a sketch from Chappelle's Show where Charlie Murphy plays Prince in basketball. Sometimes simply "blouses" is used.
*Right after dunking the winning basket home*
Prince: Game blouses.
game blouses by gameblouses December 29, 2009

Game Ovaries 

What you say when you hit a woman in the spot where her Ovaries are located.

As seen on Tosh.0, it hurts. It's funny, but it hurts.
Hayley: Hey Jess?
Jess: Yeah?
Hayley: *PUNCH* Game Ovaries!
Jess: That's funny! And it really hurt! ;D
Hayley: Yeah... :I

Game of Thrones Disease 

The act of killing off characters that fans like the most, and/or a large amount of characters in a short amount of time.
Everyone loves Tyrion, that probably means that he will probably catch Game of Thrones Disease.