Duff 

Kill me now or shoot me now

Duff me now

Duff by 😂❤️💩 March 9, 2015

duff 

that ONE ugly, unpopular person in a group of popular, or hot people. (DUFF stands for designated ugly fat friend.)

Jack: Wow, she doesn't fit in at all. She must be the duff out of that group.

duff by turtles.166 June 29, 2015

DUFF 

Designated Ugly Fat Friend

One who accompanies two other girls to make them look better. Usually, without their own knowledge.

There were two pretty girls accompanied by an uglier, fatter girl. The other girl was a DUFF, only there to make the other girls look better.

DUFF by wolfles July 27, 2015

Duff 

For ones pancreous to explode or nearly do so. Duffing is extremely painful and will require immediate medical attention to avoid a mild case of death.

1. Oh my god! I think my pancreas is duffing!

2. Man, you better slow down on the drinking, you don't want your pancreas to duff..

Duff by ailsaizzy March 18, 2009

Duff 

A polite way of saying "Gay". Named after the Hillary Duff Commercial in which she states that saying "Gay" is wrong.

You look so Duff when you dance.

Crocs are really Duff.

Duff by dramageeek September 16, 2009

Duff 

A unit of measure that quantifies the rigidity (hardness and gurth) of an erection.

"This girl I destroyed last night was so hot, I swear my dick was pulling seven or eight duffs, bro."

Duff by Pip3s November 3, 2009

Duff 

Duff is a sweet desert or pudding eaten after the main meal.

It is never a savory meal like post-scran-scran, and is not eaten before a meal like pre-scran-duff.

Napa - Great scran mate, whats for Duff?
Bill - Triffle
Napa - Awesome!

Duff by Napa Ben May 5, 2011