For ones pancreous to explode or nearly do so. Duffing is extremely painful and will require immediate medical attention to avoid a mild case of death.
1. Oh my god! I think my pancreas is duffing!
2. Man, you better slow down on the drinking, you don't want your pancreas to duff..
2. Man, you better slow down on the drinking, you don't want your pancreas to duff..
by ailsaizzy March 14, 2009