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Definitions by ailsaizzy

For ones pancreous to explode or nearly do so. Duffing is extremely painful and will require immediate medical attention to avoid a mild case of death.
1. Oh my god! I think my pancreas is duffing!

2. Man, you better slow down on the drinking, you don't want your pancreas to duff..
Duff by ailsaizzy March 18, 2009