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Slang for Mandrax, the British brand name for the sedative methaqualone, also sold by Rorer (later Lemmon) as Quaalude. A very popular drug of abuse in the late 70s but was eventually placed on DEA Schedule 1 and is no longer in manufacture.
Wanna buy some Mandies, Bob? -- spoken by Frank Zappa in the song "Flakes" on the album "Sheik Yerbouti"
mandies by Johnny Watt December 30, 2012

Sean Madden

A genious who is often asked if his uncle or grandfather is The "John Madden"..

He always repies with a smart comment ..but then continues his work
"HOLY SHIT its John Maddens Nephew.. right.. Sean Madden ..right..aww damn!"
Sean Madden by Mr Creepay January 30, 2009
a follower of the Grand Master Maddie.
A Maddite would sacrafice anything to make his or her master happy.
Maddite by Grand Master Maddie April 28, 2005

maddenfluenza 

when someone appears to lose their goddamn lives to madden...some symptoms include

dreaming about tom brady in bed with you,

beating your friends up because they cant run the ball,

trying to start a movement to make madden cards real to allow real life cheat codes

and last but not least, 1000 out of 1000 gamerscore in the xbox 360 version of it...
dude billy is like so obsessed with madden i think he has a case of maddenfluenza...i heard zack selwyn from G4 can help treat that condition

yo man my maddenfluenze has me dreaming about groping tom brady!!! sexy right?

haha you only average 1.2 yards a carry with ladanian tomlinson! now ima give you an alabama attitude lesson

you know if madden cards were real id be able to but a stephen gostkowski card and kick a ball from my house to the gas station 6 blocks away!!! make them real!

guy: hahahaha little noob i have a 1005 gamerscore stupid noob you have like 500

other guy: ya because you suck at every other game and play madden for easy achievements...face me in gears of war or call of duty 4 and you will die

guy: shut up randy moss pwns!

Madden Arcade

A very embarrassing, spirit crushing move used only by the epitome of Madden/Madden Arcade players in which you dodge an opponents player using only your joysticks.

This may cause the other player to ear rape you with constant profanity as you have made them fail so badly that they look like a fool with their pants on the ground.
"Hahaha! You have just been Madden Arcaded. How do you feel?"
"I feel like fucking you sideways with a pitchfork. That was bullshit and I bet you can't do it again."
1. Amazing; Charming; a young girl who captivates all with her smile, beauty, and poise.

2. Blonde-haired blue-eyed young lady, elegant in presence and sweet in disposition. Very lovable and amiable.
Wow, she is a real Maddi!

The world needs more Maddis in the world.

The young lady had a Maddial quality.
Maddi by Edwardian Knight May 31, 2017