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Holy Fucking Chicken-Fried Shit Patties 

An exclamation of surprise akin to "holy shit," designed for situations or events for which it would be necessary to use something crazier than "holy fucking shit."
Max: "Hey look, you're ex is making out with that guy you hate!"
Me: "Holy fucking chicken-fried shit patties!"

Holy Fucking Jesus

An expression used when something cool or mind blasting happens or is seen.
Holy Fucking Jesus!, that woman isn't a woman...it's a whale!

holy fucking shit 

An exclamation of surprise, exasperation, indignation and wonder.
Holy fucking shit, Hillary said she's running in 2004.

Holy fucking Santa clause shit

An expression used when something crazy just happened.
Derived from the movie Step Brothers
Guy 1- I just won the lottery. No big deal.

Guy 2- Holy fucking Santa clause shit that's awesome!

Holy Fucking Shit 

HFS: An acronym standing for Holy Fucking Shit, mainly used for things that require more than just a "Fuck" or a "Shit."
Person 1: Bro someone left a huge dook in the toilet bowl!
Person 2: HOLY FUCKING SHIT!

holy fuckin shit 

"holy fuckin shit" is the adult version of "OMG". When a person is in complete awe or disbelief of a sensory input, this term is commonly used. It is a modified version of the much used "holy shit", only intensified by the versatile word fuck. It is usually used in extreme cases of all kinds.
"Holy fuckin shit that pizza is hot!!"
holy fuckin shit by talkie tooter February 22, 2012