esé 

Like most curse words, it can be friendly, but calling someone an ese is the english equivalent of "you damn (insert mild curse)"

Hey I'm talkin' to you, ese!

esé by lalala November 3, 2003

Esé 

Your typical mexican equivalent of nigger.

Esé's enjoy shooting people and smoking weed in their free time. Become hostile when poked with sticks.

Juan Carlos: "Ayy esé what it is?"
*Gunshots*
Parbrecito Pedro: "Ayy he's dead esé!"

Esé by Juan Pedro Carlos Ese Rodrigue August 2, 2016

esé 

Homie, homeboy, homegirl, etc.

Esé, please. Get real.

esé by BabydollDame22 January 2, 2017

Esé 

you know how in on my block you see cholos calling other fellow cholos Esé? tip for you white boy, don't.

" ai, whattup fool "

" whattup esé "

ur white ass: what's up guys ☺️

Esé by diemundd November 29, 2021

ese wey 

Used heavily in El Paso, Texas and Ciudad Juarez, Chihuaha, Mexico. Term used to describe “that dude” which or who is acting stupid, badass, or smartass.

Some guy being flirtatious with the teacher.
Guy:“you’re pretty miss”
Classmates:”ese wey”

ese wey by Pachy September 18, 2020

ese wheels 

A foo in a wheel chair that is G'd out

Puto 1: Aye Holmes you seen ese wheels around or nah.
Puto 2:Nah foo and I ain't tryna start anything with that foo.

ese wheels by Shootergang909 June 15, 2018

ese loco 

1.a crazy motherfucker. 2. A devoted fan of Slightly Stoopid and member of their street team.

G: "Stop playing around wit me son or I'm gonna slit open yo bitch ass gizzad..."

Juan: "Hey take it easy homes! No need to act all ese loco n' shit."

or

Stoner Sam: Hey bro, you going to see Stoopid in Philly?

Harry Hed: Fuck ya, I'm an ese loco so I get backstage passes!

ese loco by AcidHead November 16, 2007