Holy shit, Jesus fucking Christ! What the fuck!?! 

A response to someone who is/was doing an action that is morally wrong, such as murder.

Holy shit, Jesus fucking Christ! What the fuck!?! You just killed the man!

Holy shit, Jesus fucking Christ! What the fuck!?! by Not a Dictionary March 8, 2021

Holy Fucking Tits 

When Holy Fucking Shit just won't cover it.

HOLY FUCKING TITS BATMAN!!

Holy Fucking Tits by ExDonnie May 17, 2010

Holy Fucking Chicken-Fried Shit Patties 

An exclamation of surprise akin to "holy shit," designed for situations or events for which it would be necessary to use something crazier than "holy fucking shit."

Max: "Hey look, you're ex is making out with that guy you hate!"
Me: "Holy fucking chicken-fried shit patties!"

Holy Fucking Chicken-Fried Shit Patties by Sanitariumchild420 March 9, 2011

Holy Fucking Jesus

An expression used when something cool or mind blasting happens or is seen.

Holy Fucking Jesus!, that woman isn't a woman...it's a whale!

Holy Fucking Jesus by f00dnetw0rk June 21, 2010

holy fucking shit 

An exclamation of surprise, exasperation, indignation and wonder.

Holy fucking shit, Hillary said she's running in 2004.

holy fucking shit by harry flashman July 8, 2003

Holy fucking Santa clause shit

An expression used when something crazy just happened.
Derived from the movie Step Brothers

Guy 1- I just won the lottery. No big deal.

Guy 2- Holy fucking Santa clause shit that's awesome!

Holy fucking Santa clause shit by Easton hockey July 22, 2009

Holy Fucking Shit 

HFS: An acronym standing for Holy Fucking Shit, mainly used for things that require more than just a "Fuck" or a "Shit."

Person 1: Bro someone left a huge dook in the toilet bowl!
Person 2: HOLY FUCKING SHIT!

Holy Fucking Shit by Mac-role Roll May 17, 2018