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The tendency for the lead singer of a rock band to become egotistical and impossible to work.

There are a number of factors that can contribute to the onset of LSD including; a natural tendency in the singer to act like a prima donna and treat other people like shit, the level of fame and fortune the band manages to achieve (whether deserved or not), how quickly the band goes from being dirt poor and unknown to filthy rich and overly famous, and whether or not other members of the band have enough talent to compete with the singer for the public and the media's attention.

LSD is often fatal… …for the band. Once a singer develops LSD there is very little hope of them ever recovering from it.

PLAIN ENGLISH VERSION: Lead singer's disease is what happens when a lead singer lets the success of their band go to their head, starts acting like he or she is god and begins to demand that everything be done their way. If they don't get their way their inflated ego makes them think that they don't need the other band members and the band splits up.
Who do you think is a worse case of lead singer's disease, Axl Rose or David Lee Roth?
by amoebabadass December 9, 2008
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Second male lead syndrome is when you like the Second Male Lead more than the Male Lead.
The Heirs - You like Choi Yound Do more than Kim Tan. You got second male lead syndrome.

" OMG ! I feel so bad for the second male lead! #secondmaleleadsyndrome "
by glow_z February 23, 2014
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Second Lead Syndrome

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Wanting so desperately for the lead actress of a drama to end up with the better guy, but you always know that she is going to end up with the lead bad guy in the end. Usually goes with the feelings of either wanting to curl up and cry over your ramen, knock someone's teeth in or both.
Me: In the drama "You're Beautiful" park shin-hye should end up with jung yong-hwa instead of jang keun-suk. Friend: Oh you definitely have second lead syndrome
by JJproject1004 November 22, 2014
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second lead syndrome

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Second Lead Syndrome is the closet thing to death that isn't. Second Lead Syndrome is when you are casually watching your Kdrama and you starts to ship the female lead with the second male lead. Or when you start to fall for the second male lead.

This feeling is horrible because you shouldn't be rooting for the second lead in this love triangle but you are, it's like an identity crisis.
"So I was watching my Kdrama last night and started getting second lead syndrome"
"You what?!"
"No cap. It's horrible but I can't stop."
by hoteldel_leejieun October 23, 2020
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lead someone on

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Saying you love someone when you don't. Kiss someone even if you don't like them.
lead someone on - She says "I love you." when she does not.
by aliaern November 22, 2013
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lead someone on

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To make a person believe a relationship is deeper than it actually is.
Always be upfront about your feelings in relationships. You don't want to lead someone on.
by selkiie101 August 5, 2022
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