Duf

An acronym for Designated Ugly Friend. Every hot girl has a DUF simply to make her look that much hotter. This strategy also works for average looking girls.

Hey Bill, here comes Mary and her DUF. I call Mary!

by Ryan June 17, 2004

Duf

Designated Ugly Friend

Britney: Oh my god, why is she your friend?
Jessica: I know shes ugly, but shes my duf.

by Scarlett_the_Slayer November 7, 2018

DUF

Designated Ugly Friend - the one obligatory fat chick in every group of hot chicks. see running interference

Damn, all those chicks are hot except for that one. Bailey's gonna take the duff home tonight.

by AspiringdeitY August 5, 2003

duf

designated ugly friend

"Dude that chicks UGLY!"

"Yes, she's the duf in the group."

by Stefany Nowak July 26, 2007

duf

short for dueche fag

you shouldn't have done that you duf

by Jacob Smith February 5, 2004

Duf

Duf is a ugly fat girl in your friend ship every body has one and there friend is much hotter than she is

I'm totally the duf in our friendship she so much hotter

by Duf4466 June 23, 2020

DUF

DUF is a word used by the almighty René Lund Chetronoch it's used to describe an action that leads something related to biotechnolegy or Ideahistory.

Look at this proteinsyntese, DUF, now we have proteins.
Then the Nazis came, DUF, world war 2.

by SebTheSnake January 6, 2022