A skizzle is when a person or pet takes a shit then proceeds to drag their ass on the floor leaving behind a streak of feces.
Skizzle is basically slang for "skidmark".
"Look! That ugly fuck just made a skizzle on the ground over there!"
Pretty much whatever you want it to mean, it's an on going joke to trickpeople into believing that their is something on their shoe, face, clothes, or any other place on the body.
The name Skizzle was given to me by my boyfriend... he sees the word as meaning "the best thing there ever was... the coolest thing..".. it can mean whatever you want it to mean. Depending on the context you use it in, it can be an insult, or a compliment.
"You're my skizzle 4 life... you're the shit." - Good use.
"Damn, that foo dang needs to get his skizzle-ass a job!"